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Affinity Capillary Electrophoresis in Pharmaceutics and - download pdf or read online

By Reinhard H. H. Neubert, Hans-Hermann Ruttinger

ISBN-10: 0824709519

ISBN-13: 9780824709518

The authors provide ideas to discover and represent interactions among medicines, drug autos, and organic membranes to facilitate advancements in managed drug supply and concentrating on. The publication comprises present purposes and approaches to spot binding constants among medicines, organic constructions, proteins, nucleic acids, and plasmids, elevate drug bioavailability, increase the permeability, solubility, energy, and serve as of drug formulations, research protein-protein exchanges and reactions, and calculate pKa values.

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Extra resources for Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics

Example text

In addition, the theoretical consideration for different models employed so far is discussed. B. Theory and Method 1. Theory For a monobasic weak acid, HA, the thermodymanic dissociation constant (K tha ) is defined as follows: K ath = ␥AϪ {Hϩ}[AϪ] ␥AϪ ϫ = KЈa ␥HA [HA] ␥HA (1) where ␥ is an activity coefficient and {Hϩ} is the activity of a proton.

Generally, the capacity factor increases with the surfactant concentration. However, the maximum concentration feasible in practical work is limited, since an increase in concentration also increases the current flowing and, hence, Joule heating. The selectivity can easily be manipulated in MEKC. For instance, selectivity changes significantly when the physicochemical proprties of the micelles are varied by using different surfactants with different structutre or alkyl chain length. Additionally, MEKC can be performed utilizing bile salts or microemulsions.

Edge of the peak). Those diffusing into the buffer downstream are accelerated too, but they are drawn away from the solute zone (skewed peak front). Neutral species remain unaffected by electrodispersion, giving rise to symmetrical peaks. An example electropherogram illustrating peak fronting and peak tailing is shown in Figure 5. Interactions between the solutes and the capillary wall also have a negative effect on the efficiency in capillary zone electrophoresis. Both hydrophobic interactions and electrostatic interactions of cations with the negatively charged capillary wall can be the cause of solute adsorption.

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Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics by Reinhard H. H. Neubert, Hans-Hermann Ruttinger


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