By Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)
Basic examine on osteoarthritis has been performed customarily from the his tological and biochemical features of the degenerating chondrocytes, collagen fibers, and matrix proteoglycans. Undue mechanical pressure has been proven to be the critical consider the initiation of osteoarthritis. even supposing the precise method through which mechanical rigidity ends up in the full destruction of cartilage tissue continues to be doubtful, numerous new examine equipment have enabled us to realize a deeper realizing of the method of degeneration. In October 1997, we geared up a global symposium titled "Ad vances in Osteoarthritis" in Kobe, with the most subject matters being up to date re seek, prognosis, and therapy of osteoarthritis. The court cases of the symposium are provided the following in 5 sections: (1) Mechanical pressure and reactions of chondrocytes, comparable to intracellular ion alterations, adjustments within the cytoskeleton, intracellular messenger platforms, unlock of gasoline mediators, and alterations in electromechanical homes of cartilage; (2) useful prognosis of osteoarthritis via MR imaging, and utilizing calpain and collagenase III as new cartilage markers; (3) remedy with a promising basic washout approach and IL-1RA and MMP antagonists; (4) Cartilage fix via new grafting tech niques; and (5) difficulties following overall joint substitute. We essentially desire that the complex wisdom supplied during this quantity of court cases may be precious to our readers.
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Extra resources for Advances in Osteoarthritis
This work was financially supported by grants from the University of Kuopio, the North Savo Fund of the Finnish Cultural Foundation, the Finnish Cultural Foundation, the Academy of Finland, the Sigrid Juselius Foundation, and the Finnish Research Council for Physical Education and Sports, Ministry of Education. References 1. Tammi M, Paukkonen K, Kiviranta I, et al (1987) Joint loading-induced alterations 2. 3. 4. 5. in articular cartilage. In: Helminen HJ, Kiviranta I, Tammi, M, et al (eds) Joint loading-Biology and health of articular structures.
In line with previous results , increased heat-shock protein 70 mRNA levels were observed, peaking at 6h of continuous pressurization, and the protein level began to accumulate accordingly (Fig. 4). Proteoglycan Synthesis 1 Control 2 3 1 4 5 30MPa 6 7 27 8 FIG. 3. Proteoglycans synthesized during 4-h labeling periods starting 0, 8, 24, or 48 h after release of continuous 30-MPa hydrostatic pressure (lanes 5, 6, 7, 8) and corresponding control cultures (lanes 1, 2, 3, 4). 25 1 2 3 6 9 12 h hsp70 hsp90 GAPDH B 0 1 30 MPa static 3 5 7 9 12 h ~hSP70 hsc70 1- 30 MPa cyclic --- -- ~hSP70 hsc70 FIG.
As regards their expression during development, chondrocytes contain type I collagen mRNA only at the very early stages of chondrogenesis , while collagen type II transcripts are detectable in the chick limb bud slightly earlier than those of aggrecan and link protein, the latter two appearing at the stage when chondrogenesis begins morphologically . During skeletal development, an identical pattern for aggrecan and link protein synthesis was noticed by in situ hybridization , and type IX collagen had an expression pattern very similar to that of aggrecan .
Advances in Osteoarthritis by Jill P. G. Urban, Robert J. Wilkins (auth.), Seisuke Tanaka M.D., Chiaki Hamanishi M.D. (eds.)